Prentice is a member of various civic and political organizations including:
Prentice attended Phoenix College; Youngstown State University, St. Joseph's Hospital School of Nursing in Phoenix and the University of Washington. A nurse for more than 20 years, she worked in various capacities, including hospital administrator and various assignments as a registered nurse. She also served as a member of the Renton school board.
She has three children and five grandchildren.
2009 Senate Bill 5254 (Granting authority to a watershed management partnership to exercise powers )
"Introduced by Sen. Margarita Prentice, (D-Renton) (D) on January 19, 2009, authorizes a watershed management partnership to exercise powers of its forming governments, including the power of eminent domain. (See also Companion HB 1332)."